CJC-1295 no DAC 5mg (Mod GRF 1-29)

CJC-1295 No DAC 5mg (Modified GRF 1-29) is a high-purity synthetic peptide analogue available exclusively at The Peptide Store, engineered for advanced somatotropic signaling, neuroendocrine regulation, and pharmacokinetic stability research. Manufactured to ≥98% purity and verified by HPLC and mass spectrometry, this compound represents a premium biochemical tool for investigative laboratory use. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

CJC-1295 No DAC, also widely referenced as Modified GRF (1-29) or Tetrasubstituted Growth Hormone-Releasing Hormone (1-29), is a synthetic analogue modeled after the biologically active core fragment of endogenous growth hormone-releasing hormone (GHRH₁₋₂₉). At The Peptide Store, this compound is offered as a rigorously quality-controlled research reagent intended for in vitro and preclinical laboratory investigations focused on pituitary somatotroph dynamics, GHRH receptor affinity studies, and adenylate cyclase activation mechanics. It is distinct from CJC-1295 with DAC in that it preserves the natural pulsatile rhythm of growth hormone secretion patterns, making it a preferred tool for researchers studying physiological GHRH signaling without permanent receptor occupancy.

Peptide Structure & Amino Acid Sequence

CJC-1295 No DAC is a 29-amino acid peptide derived from the native GHRH sequence, incorporating four strategic amino acid substitutions that confer enhanced enzymatic resistance and receptor binding stability. These substitutions are positioned to protect the peptide from rapid dipeptidyl peptidase IV (DPP-IV) cleavage, a primary mechanism of endogenous GHRH degradation in biological systems. The result is a structurally refined analogue with significantly improved in vitro half-life compared to native GHRH, while retaining full agonist activity at the GHRH receptor. The molecular formula and sequence architecture make it an ideal biochemical probe for studying receptor-ligand interactions within the somatotropic axis.

Chemical & Physical Characteristics

• Peptide Name: CJC-1295 No DAC (Modified GRF 1-29)
• Sequence Length: 29 amino acids
• Molecular Weight: Approximately 3367.9 Da
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in aqueous buffers under standard laboratory conditions
• Purity: ≥98% as verified by HPLC
• Storage Temperature: −20°C (long-term); 2–8°C (short-term)

Purity & Analytical Verification (HPLC & MS)

Every batch of CJC-1295 No DAC 5mg supplied by The Peptide Store undergoes stringent analytical verification prior to release. Reverse-phase high-performance liquid chromatography (RP-HPLC) is employed to confirm peptide purity at ≥98%, with full chromatographic trace documentation available upon request. Mass spectrometry (MS) analysis confirms the correct molecular weight and sequence integrity, ensuring that the compound delivered to researchers is free from truncated sequences, deletion peptides, or process-related impurities. This dual-method analytical approach provides researchers with the confidence required for reproducible, publication-quality experimental outcomes.

Quality Control & Lyophilization Integrity

The lyophilization process applied to CJC-1295 No DAC at The Peptide Store is conducted under controlled pharmaceutical-grade conditions to preserve structural integrity, bioactivity, and long-term stability. Lyophilized peptides are inherently more stable than liquid formulations, reducing the risk of degradation during transit and storage. Each unit is sealed under inert atmosphere conditions to minimize oxidative and hydrolytic degradation. Batch-specific certificates of analysis (CoA) documenting purity, identity, and physical characteristics accompany every order, supporting full traceability for laboratory records and research documentation.

Safety, Handling & Laboratory Precautions

CJC-1295 No DAC 5mg is intended strictly for qualified researchers and trained laboratory professionals operating within appropriately equipped research facilities. Standard laboratory personal protective equipment (PPE) including gloves, lab coat, and eye protection should be worn when handling this compound. Avoid inhalation of lyophilized powder. This peptide should be handled in accordance with institutional biosafety guidelines applicable to synthetic peptide reagents. This compound is not approved for any human or animal administration and must not be used outside of a controlled research environment.

Reconstitution, Packaging & Storage

CJC-1295 No DAC 5mg is supplied as a sterile lyophilized powder in sealed, clearly labeled research-grade vials. Reconstitution should be performed using appropriate laboratory-grade solvents such as sterile water or acetic acid buffer, strictly within a laboratory setting and in accordance with institutional protocols for peptide reagent preparation. Once reconstituted, the solution should be stored at 2–8°C and used within a timeframe consistent with established peptide stability guidelines. Unopened lyophilized vials should be stored at −20°C away from light and moisture to maintain full analytical integrity.

Intended Research Use & Market Positioning

CJC-1295 No DAC (Modified GRF 1-29) is positioned as a leading research-grade GHRH analogue for use in neuroendocrinology, metabolic biochemistry, and pituitary physiology research. Its enhanced stability profile relative to native GHRH, combined with preserved pulsatile signaling characteristics, makes it a highly sought-after tool for investigators studying growth hormone axis regulation, adenylate cyclase pathway activation, and somatotroph cell biology. The Peptide Store supplies this compound to academic institutions, pharmaceutical research organizations, and independent research laboratories worldwide.

Ordering, Availability & Fulfillment

Buy CJC-1295 No DAC 5mg online today from The Peptide Store — your trusted source for premium research peptides at competitive prices. We offer fast, discreet, and reliable fulfillment with tracked shipping to most international destinations. All orders are processed promptly, with batch-specific CoA documentation included. Order now to take advantage of our best price guarantee and experience the quality and consistency that research professionals rely on.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. CJC-1295 No DAC 5mg is sold exclusively as a laboratory research reagent. It has not been evaluated or approved by any regulatory authority for therapeutic, prophylactic, or diagnostic use in humans or animals. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the purchase, handling, and use of research peptides. The Peptide Store assumes no liability for misuse of this product outside its intended research application.