MK-677 (Ibutamoren) 12.5mg (60 Capsules)

The Peptide Store supplies MK-677 (Ibutamoren) as a highly stable, orally active non-peptide small molecule, precisely encapsulated at 12.5mg per capsule across a 60-count format. Manufactured to ≥98% purity and verified by HPLC and mass spectrometry, this compound is engineered exclusively for advanced laboratory research into somatotropic axis signaling, ghrelin receptor pharmacology, and IGF-1 transcription dynamics. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

MK-677, also known by its common research designation Ibutamoren, is a spiroindoline-derived, non-peptide growth hormone secretagogue receptor (GHSR) agonist. Unlike conventional peptide-based secretagogues that are susceptible to rapid enzymatic degradation in gastric environments, MK-677 demonstrates exceptional oral bioavailability and structural resilience. This makes it a uniquely versatile tool compound for longitudinal in vitro and ex vivo research models. The Peptide Store offers this compound in a precision-dosed encapsulated format, providing laboratories with a standardized, reproducible vehicle for multi-cohort experimental designs and metabolic flux investigations.

Peptide Structure & Amino Acid Sequence

MK-677 is classified as a small molecule rather than a classical peptide and therefore does not possess a traditional amino acid sequence. Its chemical architecture is built around a spiroindoline core scaffold, which confers high selectivity for the GHSR-1a receptor subtype. This structural configuration mimics the endogenous ghrelin ligand at the receptor binding site without the conformational lability associated with peptide chains. Its molecular formula is C₂₇H₃₆N₄O₅S, and it carries a molecular weight of approximately 528.66 g/mol. The CAS registry number for MK-677 is 159752-10-0.

Chemical & Physical Characteristics

MK-677 presents as a white to off-white crystalline powder prior to encapsulation. It exhibits high lipophilicity, contributing to its favorable oral stability profile and prolonged receptor engagement in research assays. Key physicochemical parameters include:

• Molecular Formula: C₂₇H₃₆N₄O₅S
• Molecular Weight: ~528.66 g/mol
• CAS Number: 159752-10-0
• Appearance: White to off-white crystalline powder (encapsulated)
• Solubility: Soluble in DMSO and ethanol; limited aqueous solubility
• Receptor Target: GHSR-1a (Ghrelin Receptor)

Purity & Analytical Verification (HPLC & MS)

Every batch of MK-677 supplied by The Peptide Store is manufactured to a minimum purity of ≥98%, confirmed through high-performance liquid chromatography (HPLC) and corroborated by mass spectrometry (MS) analysis. These dual-method analytical protocols ensure the compound’s identity, potency, and freedom from extraneous synthesis by-products. Certificates of Analysis (CoA) reflecting batch-specific HPLC chromatograms and MS fragmentation data are available upon request, supporting full traceability for research documentation and institutional compliance requirements.

Quality Control & Lyophilization Integrity

MK-677 in capsule format undergoes rigorous quality control at each stage of the manufacturing pipeline, from raw material sourcing through final encapsulation. Each 12.5mg capsule is filled under controlled conditions to ensure dose uniformity and content consistency across the full 60-count unit. Encapsulation integrity is verified to prevent moisture ingress, oxidative degradation, and content variance. Unlike lyophilized peptide vials, the encapsulated format offers inherent structural stability without requiring reconstitution, reducing pre-assay handling steps and minimizing preparation-related variability in research workflows.

Safety, Handling & Laboratory Precautions

MK-677 is a potent bioactive research compound and must be handled exclusively by trained laboratory personnel in compliance with institutional biosafety guidelines. Appropriate personal protective equipment (PPE), including nitrile gloves, laboratory coat, and eye protection, should be worn at all times during handling. Avoid inhalation of fine particulates. This compound is strictly for in vitro and ex vivo laboratory research applications only. It must not be administered to humans or animals under any circumstances.

Reconstitution, Packaging & Storage

As an encapsulated compound, MK-677 from The Peptide Store requires no reconstitution for standard research assay preparation. Capsules should be stored in a cool, dry environment away from direct light and humidity. Recommended storage temperature is between 2°C and 8°C for extended stability. Each order is packaged in a tamper-evident, clearly labeled container to maintain compound integrity during transit and laboratory storage. Always reseal packaging promptly after use.

Intended Research Use & Market Positioning

MK-677 is positioned as a premier tool compound for researchers investigating somatotropic axis modulation, GHSR-1a pharmacodynamics, pulsatile growth hormone secretion patterns, and systemic IGF-1 regulation. It is also widely utilized in metabolic research models examining energy homeostasis, nitrogen retention signaling, and neuroendocrine feedback loops. The Peptide Store supplies this compound to qualified research institutions, academic laboratories, and preclinical research teams seeking a reliable, high-purity source.

Ordering, Availability & Fulfillment

Buy MK-677 Ibutamoren 12.5mg capsules online today through The Peptide Store. Our inventory is maintained in-stock for prompt dispatch, with orders typically processed and fulfilled within one to two business days. We offer competitive best-price guarantees on all research compounds, with secure checkout and discreet, research-compliant packaging. Order now to ensure uninterrupted supply for your ongoing laboratory programs.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. MK-677 (Ibutamoren) is sold exclusively as a laboratory research compound by The Peptide Store. It is the sole responsibility of the purchasing institution or researcher to ensure compliance with all applicable local, national, and international regulations governing the acquisition, storage, and use of research chemicals. The Peptide Store makes no therapeutic, medical, or health-related claims regarding this compound.