P21 (P021) 5mg

P21 (P021) is an advanced synthetic neurogenic peptide derivative modeled after ciliary neurotrophic factor (CNTF), supplied by The Peptide Store at ≥98% purity in lyophilized form. Engineered for precise laboratory investigations into neurogenesis, synaptic plasticity, and memory-enhancement pathways within neurodegenerative research models, this compound represents a cutting-edge tool for neuroscience researchers worldwide. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

P21, also designated P021, is a novel synthetic tetrapeptide derivative developed as a stable, blood-brain barrier-permeable functional mimic of Ciliary Neurotrophic Factor (CNTF). Unlike native CNTF — which exhibits poor pharmacokinetic profiles and a tendency to elicit neutralizing antibody responses — P21 has been structurally optimized to overcome these limitations. The compound is available for sale through The Peptide Store, offering neuroscience laboratories a highly pure, analytically verified reagent to explore cell-autonomous neurogenesis, dentate gyrus restoration, and cellular repair mechanisms under controlled in vitro and in vivo research conditions.

Peptide Structure & Amino Acid Sequence

P21 is a modified tetrapeptide built upon the core sequence Asp-Gly-Gly-Leu (DGGL), derived from a functional domain of CNTF known to interact with the gp130 signaling receptor complex. To enhance lipophilicity, membrane permeability, and resistance to plasma peptidase degradation, an adamantyl moiety is appended at the C-terminus. This structural modification significantly improves the compound’s ability to traverse the blood-brain barrier compared to its parent protein, making it a uniquely valuable tool for central nervous system (CNS) research applications. The adamantylated DGGL sequence represents a precision-engineered neurotrophic strategy with well-characterized receptor engagement properties in preclinical research settings.

Chemical & Physical Characteristics

• Peptide Name: P21 (P021)
• Core Sequence: DGGL (Asp-Gly-Gly-Leu)
• Modification: Adamantyl moiety at C-terminus
• Molecular Class: Synthetic modified tetrapeptide
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in standard aqueous research buffers and organic co-solvents under controlled laboratory conditions
• Purity: ≥98% (HPLC verified)

Purity & Analytical Verification (HPLC & MS)

Every batch of P21 supplied by The Peptide Store undergoes rigorous analytical testing to confirm identity and purity. High-Performance Liquid Chromatography (HPLC) analysis confirms a minimum purity of ≥98%, ensuring that each vial contains a highly homogeneous compound with minimal impurities or degradation byproducts. Mass Spectrometry (MS) is employed to verify the precise molecular weight and structural integrity of the peptide, confirming the correct adamantyl-DGGL architecture. Certificates of Analysis (CoA) reflecting these analytical results are available upon request, providing full traceability and quality assurance for research procurement decisions.

Quality Control & Lyophilization Integrity

P21 is supplied in a lyophilized (freeze-dried) format, which is the industry-standard method for preserving peptide stability over extended periods. The lyophilization process removes residual moisture under vacuum conditions, minimizing oxidative and hydrolytic degradation pathways. Strict quality control protocols are applied at every stage of manufacturing, from raw material sourcing through final lyophilization and vial sealing. Each unit is individually inspected to confirm physical integrity before dispatch, ensuring that researchers at The Peptide Store receive a product that meets the highest standards of laboratory-grade quality.

Safety, Handling & Laboratory Precautions

P21 is intended exclusively for use by trained laboratory personnel operating within appropriately equipped research facilities. Standard laboratory safety precautions should be observed at all times, including the use of appropriate personal protective equipment (PPE) such as gloves, eye protection, and lab coats. The compound should be handled in a manner consistent with institutional biosafety guidelines. This product is not approved for use in humans or animals and must not be used in any clinical, therapeutic, or diagnostic context.

Reconstitution, Packaging & Storage

P21 is packaged in sealed, inert vials suitable for long-term laboratory storage. Upon receipt, the lyophilized powder should be stored at -20°C in a dry, light-protected environment to maintain maximum stability. Reconstitution should be performed using appropriate research-grade solvents or buffers as determined by the experimental protocol of the receiving laboratory. Once reconstituted, aliquoting and prompt use or re-freezing is recommended to prevent repeated freeze-thaw degradation. Packaging is designed to preserve product integrity throughout international shipping and handling.

Intended Research Use & Market Positioning

P21 (P021) is positioned as a premier research-grade neurogenic compound for neuroscience and pharmacology laboratories investigating CNTF-pathway modulation, adult neurogenesis, synaptic plasticity, cognitive function models, and neurodegenerative disease mechanisms. Its unique adamantylated structure makes it one of the most structurally optimized CNTF-mimic peptides commercially available for research procurement. The Peptide Store offers this compound at a competitive best price, making it accessible to academic institutions, contract research organizations, and independent research teams worldwide.

Ordering, Availability & Fulfillment

P21 (P021) is available to buy online now through The Peptide Store with fast, reliable fulfillment. Orders are processed promptly and dispatched with appropriate cold-chain packaging to preserve lyophilized peptide integrity during transit. The Peptide Store maintains consistent stock availability to support ongoing research programs. Researchers seeking to order P21 for sale can do so with confidence, knowing that every unit is backed by full analytical documentation and our commitment to research-grade quality standards.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. P21 (P021) is sold exclusively as a laboratory research reagent. It has not been evaluated or approved by any regulatory authority for therapeutic, prophylactic, or diagnostic use in humans or animals. All purchasers are solely responsible for ensuring compliance with applicable local, national, and international laws and regulations governing the procurement, handling, and use of research peptides. The Peptide Store assumes no liability for misuse of this product outside its intended research context.