IGF-1 LR3 1mg

IGF-1 LR3 is a premium, high-potency synthetic 83-amino-acid analog of human Insulin-like Growth Factor-1, available at ≥98% purity from The Peptide Store. Featuring a strategic arginine substitution at position 3 and a 13-amino-acid N-terminal extension, this configuration is engineered strictly for investigating sustained somatotropic signaling and uninhibited receptor binding kinetics. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

IGF-1 LR3 — biochemically designated as Long Arg3 Insulin-like Growth Factor-1 — is a structurally advanced synthetic polypeptide analog of endogenous human IGF-1. While native IGF-1 comprises a 70-amino-acid single-chain peptide, the LR3 modification expands this into a full 83-amino-acid sequence, granting researchers a uniquely potent molecular tool for high-resolution studies in cellular proliferation, metabolic signaling, and tissue biology. Available for sale at The Peptide Store with verified ≥98% purity, this compound represents a benchmark-grade reagent for serious laboratory research programs.

Peptide Structure & Amino Acid Sequence

The LR3 variant of IGF-1 is distinguished by two principal structural modifications relative to the native hormone. First, a 13-amino-acid extension is appended to the N-terminus of the standard IGF-1 sequence. Second, a site-specific substitution replaces the native Glutamic Acid at position 3 with Arginine (Glu³ → Arg³). Together, these modifications substantially reduce binding affinity to IGF-binding proteins (IGFBPs), thereby prolonging the bioavailability of the free peptide in research systems and enabling more sustained receptor engagement kinetics compared to unmodified IGF-1. This makes IGF-1 LR3 a preferred research analog for studies requiring extended somatotropic signaling windows.

Chemical & Physical Characteristics

• Full Chemical Name: Long Arg3 Insulin-like Growth Factor-1
• Sequence Length: 83 amino acids
• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
• Molecular Weight: Approximately 9,117.5 Da
• Form: Lyophilized white to off-white powder
• Solubility: Soluble in aqueous buffers; refer to laboratory protocol for solvent selection
• CAS Number: 946870-92-4

Purity & Analytical Verification (HPLC & MS)

Every batch of IGF-1 LR3 supplied by The Peptide Store is independently verified to a minimum purity threshold of ≥98%, confirmed through reverse-phase High-Performance Liquid Chromatography (HPLC). Mass Spectrometry (MS) analysis is additionally applied to confirm the precise molecular mass and sequence integrity of each production lot. These dual-method analytical procedures ensure that researchers receive a compound of consistent, publication-grade quality suitable for demanding experimental applications in endocrinology, molecular biology, and regenerative science research.

Quality Control & Lyophilization Integrity

IGF-1 LR3 is produced under stringent quality control protocols and is supplied in a lyophilized (freeze-dried) matrix. Lyophilization preserves the structural integrity of the peptide backbone, minimizes degradation during transit, and significantly extends shelf life when stored under recommended conditions. Each unit undergoes batch-level quality review prior to dispatch, and documentation supporting purity and identity claims is maintained in accordance with good laboratory practice standards. Researchers ordering from The Peptide Store can be confident in the reproducibility and reliability of each lot received.

Safety, Handling & Laboratory Precautions

IGF-1 LR3 is a research-grade chemical reagent intended exclusively for qualified laboratory professionals operating within appropriate institutional frameworks. Standard laboratory personal protective equipment (PPE) — including nitrile gloves, protective eyewear, and a laboratory coat — should be worn when handling this compound. Avoid inhalation of lyophilized powder. In the event of skin or eye contact, rinse thoroughly with water. Dispose of all materials in compliance with applicable local, national, and institutional waste regulations. This compound is not approved for any biological, clinical, or consumptive application.

Reconstitution, Packaging & Storage

IGF-1 LR3 is supplied as a lyophilized powder in a sealed, laboratory-grade vial. For research reconstitution purposes, consult your institutional standard operating procedure and applicable peer-reviewed literature for appropriate solvent selection and buffer conditions. Store the lyophilized product at −20°C in a dry, dark environment. Once reconstituted, store at 4°C and use promptly according to your validated research protocol. Avoid repeated freeze-thaw cycles, which may compromise peptide integrity. Packaging is designed to maintain sterility and stability throughout the cold-chain shipping process.

Intended Research Use & Market Positioning

IGF-1 LR3 is positioned as a premier research reagent for investigators studying somatotropic axis biology, receptor tyrosine kinase activation, anabolic signaling cascades, and IGFBP interaction dynamics. Its extended half-life profile relative to native IGF-1 makes it particularly valuable for time-course studies and long-duration in vitro experimental models. The Peptide Store offers this compound for sale to licensed researchers, academic institutions, and biotechnology organizations seeking a reliable, high-purity source of this advanced analog. It is not intended for use in humans, animals, or any clinical application.

Ordering, Availability & Fulfillment

IGF-1 LR3 is available to order now directly through The Peptide Store’s secure online platform. We offer competitive best-price guarantees, fast order processing, and reliable domestic and international fulfillment. All orders are dispatched with batch-specific purity documentation. Whether you are buying IGF-1 LR3 for a single experiment or establishing a recurring institutional supply, The Peptide Store provides a streamlined purchasing experience backed by consistent product quality and responsive customer support.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. IGF-1 LR3 is sold exclusively as a laboratory research reagent. The Peptide Store makes no representations regarding the suitability of this compound for any application beyond in vitro or ex vivo scientific research. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the purchase, possession, and use of research chemicals. This product has not been evaluated or approved by any regulatory authority for therapeutic or diagnostic use.