IGF-1 LR3 (Receptor Grade) 1mg

IGF-1 LR3 (Receptor Grade) is a premium-grade, synthetic 83-amino-acid analog of human Insulin-like Growth Factor-1, supplied at ≥98% purity in a lyophilized format. Engineered with a strategic arginine substitution at position 3 and a 13-amino-acid N-terminal extension, this configuration is designed exclusively for advanced somatotropic signaling and receptor binding research. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

IGF-1 LR3, formally designated Long Arg3 Insulin-like Growth Factor-1, represents one of the most structurally refined synthetic peptide analogs available to the research community today. Available for purchase from The Peptide Store, this receptor-grade compound is produced to meet the exacting standards demanded by molecular biology, cellular signaling, and metabolic pathway research. Its extended half-life relative to native IGF-1 and its markedly reduced affinity for IGF-binding proteins (IGFBPs) make it a preferred tool for researchers seeking sustained, uninhibited receptor activation in controlled laboratory settings.

Peptide Structure & Amino Acid Sequence

Native human IGF-1 is a 70-amino-acid single-chain polypeptide. The LR3 modification transforms this into an 83-amino-acid analog through two principal structural changes: a 13-amino-acid extension appended to the N-terminus, and a site-specific substitution of Glutamic Acid at position 3 with Arginine (Glu³ → Arg³). This dual modification is central to the peptide’s enhanced pharmacodynamic profile in vitro. The arginine substitution at position 3 dramatically reduces IGFBP binding affinity, while the N-terminal extension contributes to the molecule’s extended biological activity window — both critical variables in sustained receptor engagement studies.

Chemical & Physical Characteristics

• Peptide Length: 83 amino acids
• Molecular Weight: Approximately 9,117 Da
• Modification: Glu³ → Arg³ substitution with 13-residue N-terminal extension
• Form: White to off-white lyophilized powder
• Solubility: Soluble in aqueous buffers (research-grade solvents only)
• CAS Number: 946870-92-4

Purity & Analytical Verification (HPLC & MS)

Every batch of IGF-1 LR3 (Receptor Grade) supplied by The Peptide Store undergoes rigorous analytical verification prior to release. Purity is confirmed at ≥98% via reverse-phase High-Performance Liquid Chromatography (RP-HPLC). Molecular identity and structural integrity are independently verified through Mass Spectrometry (MS), ensuring that each unit delivered to qualified researchers reflects the precise molecular architecture required for reproducible experimental outcomes. Certificate of Analysis (CoA) documentation is available upon request.

Quality Control & Lyophilization Integrity

The receptor-grade designation assigned to this product reflects a higher tier of quality control than standard research-grade peptides. Lyophilization is performed under controlled conditions to preserve primary structure, secondary folding characteristics, and long-term molecular stability. Each vial is sealed under inert atmosphere to minimize oxidative degradation, ensuring the compound retains its analytical profile throughout its stated shelf life when stored under recommended conditions.

Safety, Handling & Laboratory Precautions

IGF-1 LR3 (Receptor Grade) is intended exclusively for use by trained researchers in properly equipped laboratory environments. Personnel handling this compound should observe standard laboratory safety protocols, including the use of appropriate personal protective equipment (PPE). This peptide is not approved for, nor intended for, any form of human or animal administration. Researchers should consult applicable institutional biosafety guidelines before handling.

Reconstitution, Packaging & Storage

This peptide is supplied in lyophilized powder form, packaged in a sealed, sterile vial suitable for laboratory handling. Reconstitution should be performed using research-grade solvents appropriate to the experimental protocol, in accordance with institutional laboratory procedures. For optimal stability, store lyophilized product at −20°C, protected from light and moisture. Once reconstituted, aliquot and store at −80°C to minimize freeze-thaw degradation cycles. Avoid repeated freeze-thaw cycles to preserve analytical integrity.

Intended Research Use & Market Positioning

IGF-1 LR3 (Receptor Grade) is positioned as a best-in-class research tool for investigators working in areas including cellular proliferation assays, metabolic signaling pathway mapping, tissue hypertrophy modeling, and somatotropic axis research. Its reduced IGFBP binding affinity and extended in vitro activity window make it especially well-suited for studies requiring sustained, consistent receptor stimulation without the interference of endogenous binding proteins. This compound is not intended for diagnostic, therapeutic, or clinical use of any kind.

Ordering, Availability & Fulfillment

Qualified researchers can buy IGF-1 LR3 Receptor Grade online directly from The Peptide Store at a competitive best price, with fast order processing and reliable fulfillment. Our inventory is maintained to ensure consistent availability for ongoing research programs. Order now to take advantage of streamlined checkout, secure payment processing, and prompt dispatch to laboratory addresses worldwide, subject to applicable regional regulations.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. IGF-1 LR3 (Receptor Grade) is sold exclusively as a laboratory research reagent. All purchases are made under the express understanding that this compound will be used solely within the scope of legitimate scientific research by qualified professionals operating in compliance with all applicable local, national, and international laws and regulations. The Peptide Store assumes no liability for misuse, improper handling, or use outside the intended research context.