IGF-1 DES 1mg

IGF-1 DES 1mg is a premium-grade synthetic 67-amino-acid truncated variant of Insulin-like Growth Factor-1, available from The Peptide Store at ≥98% purity. This advanced biochemical tool is formulated exclusively to support high-resolution molecular and cellular research applications. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

IGF-1 DES, formally designated des(1-3)IGF-1, is a naturally occurring truncated splice variant of human Insulin-like Growth Factor-1. Unlike full-length IGF-1, this variant is defined by the precise deletion of the N-terminal tripeptide sequence Glycine-Proline-Glutamate, yielding a 67-amino-acid single-chain polypeptide with a distinct receptor-binding profile. This structural modification significantly reduces affinity for IGF-binding proteins (IGFBPs), enabling researchers to investigate localized receptor activation and downstream signaling cascades with minimized confounding variables. The Peptide Store supplies this compound as a lyophilized research-grade material, manufactured under strict quality control protocols for use in pharmacology, neuroscience, and regenerative biology laboratories.

Peptide Structure & Amino Acid Sequence

IGF-1 DES is a 67-amino-acid single-chain polypeptide derived from the full 70-amino-acid IGF-1 sequence through the deletion of residues 1–3 at the N-terminus (Gly-Pro-Glu). This truncation preserves the core receptor-binding domains responsible for IGF-1 receptor (IGF-1R) engagement while dramatically altering binding protein interactions. The resulting molecule retains three intramolecular disulfide bonds critical to its tertiary structure and biological stability in vitro. Its molecular architecture makes it a uniquely valuable tool for dissecting localized versus systemic growth factor signaling in controlled laboratory environments.

Chemical & Physical Characteristics

• Peptide Name: IGF-1 DES / des(1-3)IGF-1
• Amino Acid Length: 67 residues
• Molecular Formula: C319H501N91O96S7
• Molecular Weight: Approximately 7,371 Da
• Appearance: White to off-white lyophilized powder or cake
• Solubility: Soluble in aqueous buffer systems at appropriate pH for in vitro applications
• Purity: ≥98% by HPLC

Purity & Analytical Verification (HPLC & MS)

Every batch of IGF-1 DES supplied by The Peptide Store undergoes rigorous analytical verification to confirm identity and purity. High-Performance Liquid Chromatography (HPLC) is employed to quantify purity at ≥98%, while Mass Spectrometry (MS) confirms the precise molecular weight and sequence integrity of the final product. These dual-verification methods ensure that researchers receive a compound free from synthesis-related impurities, truncated sequences, or degradation products that could compromise experimental reproducibility and data integrity.

Quality Control & Lyophilization Integrity

IGF-1 DES is produced using solid-phase peptide synthesis (SPPS) protocols under controlled manufacturing conditions. Following synthesis and purification, the peptide undergoes lyophilization—a freeze-drying process that removes residual moisture while preserving structural integrity and long-term stability. The resulting lyophilized cake is sealed under inert atmospheric conditions to prevent oxidative degradation. Each production lot is assigned a unique batch number, and corresponding Certificates of Analysis (CoA) are available upon request, providing full traceability and transparency for laboratory procurement records.

Safety, Handling & Laboratory Precautions

IGF-1 DES 1mg is intended exclusively for in vitro research use by qualified laboratory professionals. Personnel handling this material should adhere to standard laboratory safety protocols, including the use of appropriate personal protective equipment (PPE) such as gloves, lab coats, and eye protection. This compound should be handled in a designated research environment. Avoid inhalation of lyophilized powder. All waste disposal must comply with applicable institutional and regulatory guidelines for biochemical research materials.

Reconstitution, Packaging & Storage

IGF-1 DES is supplied as a lyophilized powder in a sealed, sterile vial suitable for laboratory reconstitution using appropriate research-grade aqueous solvents. For optimal long-term stability, the lyophilized product should be stored at −20°C or below, protected from light and moisture. Once reconstituted for in vitro assay use, solutions should be aliquoted, stored at −80°C, and used within a timeframe consistent with established laboratory protocols to minimize freeze-thaw degradation. Specific reconstitution volumes and buffers should be determined by the principal investigator based on experimental design requirements.

Intended Research Use & Market Positioning

IGF-1 DES is a highly sought-after biochemical tool in the fields of molecular biology, neuroscience, and regenerative medicine research. Its reduced IGFBP affinity makes it particularly valuable for studies examining localized IGF-1 receptor binding kinetics, cellular hypertrophy signaling pathways, and tissue repair mechanics in the absence of systemic binding protein interference. The Peptide Store positions IGF-1 DES as a premium, analytically verified research reagent for academic institutions, contract research organizations (CROs), and independent laboratories requiring consistent, high-purity peptide materials.

Ordering, Availability & Fulfillment

IGF-1 DES 1mg is available to buy online directly through The Peptide Store with fast, reliable fulfillment. Our streamlined ordering process ensures that qualified researchers can order now with confidence, benefiting from competitive best-price positioning, batch-specific CoA documentation, and professional customer support. All orders are processed promptly and dispatched in temperature-appropriate packaging to maintain lyophilization integrity during transit. International shipping options are available subject to applicable import regulations in the destination country.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. IGF-1 DES 1mg is sold exclusively as a laboratory research reagent. The Peptide Store makes no claims regarding therapeutic efficacy, safety for administration, or suitability for any use beyond controlled in vitro scientific investigation. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the procurement, handling, and use of research biochemicals. This product must not be used in any manner inconsistent with its research-only designation.