Kisspeptin-10 5mg

Kisspeptin-10 5mg is a premium-grade synthetic decapeptide available at ≥98% purity, representing the minimally active yet maximally potent C-terminal fragment of the KISS1 gene product. This formulation serves as an essential biochemical probe for investigating GPR54 (KISS1R) receptor kinetics, pulsatile GnRH release modulation, and neuroendocrine regulation of the hypothalamic–pituitary–gonadal (HPG) axis. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

Kisspeptin-10 is a biologically active decapeptide derived through proteolytic processing of the 145-amino-acid KISS1 gene product, commonly referred to as metastin. As the shortest functional fragment retaining full receptor-binding capacity, Kisspeptin-10 has become one of the most widely studied neuropeptides in the fields of reproductive endocrinology and hypothalamic neuroscience. The Peptide Store supplies this compound as a lyophilized research-grade reagent, manufactured under stringent quality protocols to ensure consistent, reproducible results across a wide range of in vitro and ex vivo experimental applications.

Peptide Structure & Amino Acid Sequence

Kisspeptin-10 is composed of the following 10-amino-acid C-terminal sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂. This sequence contains the critical RF-amide motif at the C-terminus, which is structurally indispensable for high-affinity binding and functional activation of the GPR54 receptor (also designated KISS1R). The amidated C-terminus is a defining pharmacophoric feature that distinguishes Kisspeptin-10 from longer precursor fragments and contributes directly to its potency as a receptor agonist in neuroendocrine signaling research models.

Chemical & Physical Characteristics

• Peptide Name: Kisspeptin-10
• Synonyms: Metastin (45–54), KP-10, KISS1 C-terminal decapeptide
• Molecular Formula: C₆₃H₈₃N₁₅O₁₂
• Molecular Weight: Approximately 1,302.4 Da
• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in aqueous buffers; water solubility confirmed at standard laboratory conditions
• Storage Temperature: −20°C (long-term); 2–8°C (short-term, desiccated)

Purity & Analytical Verification (HPLC & MS)

Every batch of Kisspeptin-10 supplied by The Peptide Store undergoes rigorous analytical testing prior to release. Purity is confirmed at ≥98% via reverse-phase high-performance liquid chromatography (RP-HPLC), ensuring minimal presence of truncated sequences, deletion peptides, or synthesis by-products. Identity is independently verified by mass spectrometry (MS), confirming correct molecular weight and structural integrity. Certificates of Analysis (CoA) reflecting these validated results are available upon request, providing full analytical transparency for research documentation and institutional compliance purposes.

Quality Control & Lyophilization Integrity

Kisspeptin-10 is manufactured using solid-phase peptide synthesis (SPPS) under controlled GMP-aligned conditions. Following synthesis and purification, the peptide undergoes lyophilization—a freeze-drying process that removes residual moisture and stabilizes the compound for long-term storage without degradation. Each vial is sealed under inert atmosphere to prevent oxidation and moisture ingress. Lot-specific quality control records document synthesis batch integrity, HPLC chromatograms, MS spectra, and moisture content, ensuring every unit delivered meets the highest standards expected by professional research environments.

Safety, Handling & Laboratory Precautions

Kisspeptin-10 is a research-grade chemical intended exclusively for qualified laboratory personnel. Standard laboratory safety protocols should be observed at all times. Appropriate personal protective equipment (PPE)—including nitrile gloves, safety glasses, and a lab coat—should be worn during handling. Avoid inhalation of lyophilized powder. This compound has not been evaluated for safety in biological systems outside controlled in vitro or ex vivo research contexts. All waste disposal must comply with applicable institutional and regulatory guidelines for synthetic peptide reagents.

Reconstitution, Packaging & Storage

Kisspeptin-10 is supplied as a sterile lyophilized powder in sealed research vials. For laboratory reconstitution, researchers should consult peer-reviewed literature and institutional SOPs relevant to their specific experimental design. The compound should be stored at −20°C upon receipt for long-term stability. Once reconstituted for in vitro use, aliquot and store per validated laboratory protocols to minimize freeze-thaw degradation cycles. Packaging is designed to maintain product integrity during international shipping and ambient temperature fluctuations encountered during transit.

Intended Research Use & Market Positioning

Kisspeptin-10 is an established biochemical tool in neuroendocrinology, reproductive biology, and hypothalamic signaling research. Its primary utility lies in probing GPR54 receptor activation, studying pulsatile GnRH secretion dynamics, and characterizing the upstream neuroendocrine architecture of the HPG axis. Additional research applications include investigation of kisspeptin’s role in puberty onset signaling, seasonal reproductive regulation, and potential crosstalk with metabolic sensing pathways. The Peptide Store positions Kisspeptin-10 as a premium, competitively priced reagent for academic institutions, contract research organizations (CROs), and independent research laboratories seeking reliable, high-purity synthetic peptides.

Ordering, Availability & Fulfillment

Kisspeptin-10 is available for purchase online through The Peptide Store with fast, discreet fulfillment and reliable international shipping options. Researchers can order now with confidence, knowing each unit is backed by full analytical documentation and consistent batch-to-batch quality. Competitive best-price positioning makes The Peptide Store a preferred source for buying research peptides online. Bulk inquiry options and institutional purchase orders are accommodated upon request. All orders are processed promptly, with tracking provided upon dispatch.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Kisspeptin-10 is sold exclusively as a laboratory research reagent. The Peptide Store makes no claims regarding therapeutic efficacy, biological safety in living organisms, or suitability for any application beyond controlled in vitro or ex vivo scientific investigation. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the acquisition, possession, and use of synthetic research peptides. By purchasing this product, the buyer confirms they are a qualified research professional using this compound within a regulated laboratory environment.