Pentapeptide-18 (Leuphasyl) 200mg (Topical)

Pentapeptide-18 (Leuphasyl) is a premium synthetic neuromodulating peptide available at ≥98% purity, formulated as a topical research reagent for advanced laboratory investigation. Engineered to biomimetically replicate endogenous enkephalin activity, this compound offers researchers a highly stable, concentrated platform for studying neurotransmitter exocytosis, neuromuscular junction signaling, and cutaneous matrix communication. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

Pentapeptide-18 (Leuphasyl) is a five-amino-acid synthetic peptide widely recognized in the research community for its biomimetic enkephalin-like properties. Available exclusively through The Peptide Store in a 200mg topical configuration, this compound serves as a premier reagent for scientists investigating localized cellular signaling, neuroendocrine skin communication, and the mechanistic down-regulation of neurotransmitter exocytosis in controlled in vitro environments. Its topical presentation makes it especially suited for cutaneous and dermal research models where localized application is required for accurate experimental outcomes.

Peptide Structure & Amino Acid Sequence

Pentapeptide-18 is defined by a precise five-amino-acid sequence: Tyr-D-Ala-Gly-Phe-Leu. This specific arrangement of tyrosine, D-alanine, glycine, phenylalanine, and leucine is responsible for the compound’s high structural affinity toward opioid receptor subtypes involved in neuromuscular junction signaling models. The incorporation of D-alanine in the second position confers enhanced metabolic stability compared to naturally occurring enkephalin analogs, making it a preferred research tool for extended in vitro experimental protocols. The sequence is synthetically manufactured to strict pharmaceutical-grade specifications to ensure batch-to-batch reproducibility.

Chemical & Physical Characteristics

• Common Name: Pentapeptide-18 / Leuphasyl
• Sequence: Tyr-D-Ala-Gly-Phe-Leu
• Peptide Class: Synthetic enkephalin biomimetic
• Molecular Formula: C₂₈H₃₈N₄O₇
• Molecular Weight: Approximately 562.63 g/mol
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in aqueous buffers and select organic solvents under laboratory conditions
• Formulation Type: Topical research configuration
• Purity: ≥98% (HPLC verified)

Purity & Analytical Verification (HPLC & MS)

Every batch of Pentapeptide-18 supplied by The Peptide Store undergoes rigorous analytical verification using high-performance liquid chromatography (HPLC) and mass spectrometry (MS) to confirm identity, purity, and structural integrity. Results consistently demonstrate ≥98% purity, ensuring that researchers receive a compound free from significant impurities, truncated sequences, or degradation byproducts. Certificates of Analysis (CoA) are available upon request, providing full traceability and analytical transparency for peer-reviewed research documentation and institutional compliance requirements.

Quality Control & Lyophilization Integrity

Pentapeptide-18 is produced under stringent quality control protocols that govern every stage of synthesis, purification, and packaging. The lyophilization process is carefully controlled to remove residual moisture while preserving the peptide’s native conformation and biological activity potential under research conditions. Lyophilized powder format ensures superior long-term stability compared to liquid formulations, reducing the risk of hydrolytic degradation during storage. Each unit is sealed under inert conditions to maintain integrity from production through delivery to the research laboratory.

Safety, Handling & Laboratory Precautions

Pentapeptide-18 is intended exclusively for use by qualified researchers and laboratory professionals in properly equipped scientific facilities. Standard laboratory personal protective equipment (PPE) — including nitrile gloves, safety eyewear, and appropriate lab coats — should be worn at all times when handling this compound. Researchers should consult the relevant Safety Data Sheet (SDS) prior to use and adhere to all institutional biosafety protocols. This compound must not be used in any human or animal subject, and must not be administered, ingested, or applied in any consumptive or diagnostic context.

Reconstitution, Packaging & Storage

Pentapeptide-18 is supplied as a lyophilized powder in laboratory-grade packaging designed to maintain compound integrity during transit and storage. For research reconstitution, researchers should consult peer-reviewed literature and established laboratory protocols appropriate to their specific experimental design. Store the lyophilized compound at −20°C in a dry, dark environment away from heat, moisture, and direct light. Under recommended storage conditions, the compound demonstrates excellent stability for extended periods. Once reconstituted for laboratory use, prepared solutions should be aliquoted and stored appropriately per standard research practice to minimize freeze-thaw degradation.

Intended Research Use & Market Positioning

Pentapeptide-18 (Leuphasyl) is positioned as a leading research-grade neuromodulating peptide for scientists focused on cutaneous neuroendocrinology, synaptic signaling models, and biomimetic enkephalin research. Its well-characterized sequence and established receptor affinity profile make it a high-value reagent for in vitro studies exploring neuromuscular junction mechanics, signal transduction pathways, and structural dermal matrix interactions. The Peptide Store offers this compound at a competitive best price, making it accessible to academic institutions, biotech research teams, and independent laboratories worldwide.

Ordering, Availability & Fulfillment

Researchers can conveniently buy Pentapeptide-18 (Leuphasyl) 200mg online through The Peptide Store’s secure eCommerce platform. We maintain consistent inventory to support ongoing research programs and offer prompt order processing with reliable international fulfillment. Competitive pricing, transparent CoA documentation, and dedicated research support make The Peptide Store the preferred destination to order Pentapeptide-18 for sale at the best price available. Contact our team for bulk inquiry pricing, institutional purchase orders, or expedited shipping options.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Pentapeptide-18 (Leuphasyl) is sold strictly as a laboratory research reagent. The Peptide Store makes no claims regarding therapeutic efficacy, safety for biological administration, or suitability for any use beyond controlled scientific investigation. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the acquisition, handling, and use of research peptides. This product must be used only by trained research professionals in authorized laboratory settings.