TRH Thyrotropin (Protirelin) 20mg

TRH Thyrotropin (Protirelin) is a synthetic tripeptide analog of thyrotropin-releasing hormone, offered at ≥98% purity for professional laboratory and research applications. Sourced and quality-verified by The Peptide Store, this compound is of significant interest in endocrine signaling, neuropeptide research, and hypothalamic-pituitary pathway modeling. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

TRH Thyrotropin (Protirelin) is a well-characterized synthetic tripeptide that mirrors the structure of endogenous thyrotropin-releasing hormone (TRH), naturally biosynthesized in the hypothalamus. In controlled research environments, Protirelin is studied extensively for its capacity to stimulate thyroid-stimulating hormone (TSH) secretion from the anterior pituitary, making it a valuable tool in pituitary-thyroid axis investigations. Its compact molecular architecture and clearly defined receptor interaction profile position it as a leading reference compound for endocrinological, neurobiological, and receptor-binding studies conducted in accredited laboratory settings.

Peptide Structure & Amino Acid Sequence

Protirelin is a synthetic tripeptide comprising three amino acid residues: pyroglutamic acid, histidine, and proline amide, presented in the sequence pGlu-His-Pro-NH₂. This minimal yet highly bioactive structure is recognized as a prototype neuropeptide for studying small-molecule hypothalamic hormones. The C-terminal proline amide modification and N-terminal pyroglutamate cyclization are structural features that researchers note as critical determinants of its receptor selectivity and metabolic stability in in vitro assay systems.

Chemical & Physical Characteristics

TRH Thyrotropin (Protirelin) presents as a white to off-white lyophilized powder under standard laboratory conditions. Its molecular formula is C₁₆H₂₂N₆O₄, with a molecular weight of approximately 362.38 g/mol. The CAS number for Protirelin is 24305-27-9. The compound is water-soluble and demonstrates stability under appropriate cold-chain storage conditions. These physicochemical properties make it compatible with a broad range of in vitro assay formats used in receptor binding, cell signaling, and endocrine pathway research.

Purity & Analytical Verification (HPLC & MS)

Every batch of TRH Thyrotropin (Protirelin) supplied by The Peptide Store is manufactured to a minimum purity specification of ≥98%, verified through rigorous high-performance liquid chromatography (HPLC) analysis. Mass spectrometry (MS) confirmation is employed to validate molecular identity and structural integrity, ensuring each lot meets exacting analytical benchmarks. Researchers can rely on consistent purity data to support reproducible experimental outcomes and reliable inter-assay comparisons.

Quality Control & Lyophilization Integrity

The Peptide Store applies comprehensive quality control protocols across the full production and packaging workflow. Protirelin is lyophilized under controlled conditions to remove residual moisture and preserve molecular stability during storage and transit. Each unit undergoes batch-level quality review, with documentation available to support laboratory compliance requirements. Lyophilization integrity is maintained through validated freeze-drying cycles that protect the peptide’s structural conformation and biological activity profile for research purposes.

Safety, Handling & Laboratory Precautions

TRH Thyrotropin (Protirelin) is intended exclusively for use by trained researchers and qualified laboratory professionals operating within properly equipped scientific facilities. Standard laboratory personal protective equipment (PPE), including gloves, eye protection, and appropriate lab attire, should be worn when handling this compound. Researchers must adhere to all applicable institutional biosafety guidelines and local regulatory requirements governing the handling and storage of synthetic peptide research materials. This product is not approved for any use outside of controlled laboratory research environments.

Reconstitution, Packaging & Storage

TRH Thyrotropin (Protirelin) is supplied as a lyophilized powder in a sealed research-grade vial, designed to maintain stability and prevent contamination during storage. For in vitro research applications, reconstitution should be performed using an appropriate aqueous vehicle under sterile laboratory conditions, following established institutional protocols. The product should be stored at -20°C upon receipt to ensure maximum long-term stability. Avoid repeated freeze-thaw cycles, and protect the compound from direct light and humidity exposure. Once reconstituted, aliquoting and prompt use are recommended.

Intended Research Use & Market Positioning

Protirelin occupies a well-established position in the research peptide market as a reference compound for hypothalamic-pituitary-thyroid (HPT) axis studies, TSH stimulation assays, and neuropeptide receptor research. It is widely utilized in academic, pharmaceutical, and contract research laboratory settings where precise endocrine pathway modeling is required. The Peptide Store offers TRH Thyrotropin (Protirelin) for sale to qualified researchers seeking a reliable, high-purity compound at a competitive best price, with consistent availability and professional fulfillment standards.

Ordering, Availability & Fulfillment

Researchers and laboratory procurement teams can buy TRH Thyrotropin (Protirelin) 20mg online directly through The Peptide Store with confidence. Our streamlined ordering process, secure checkout, and prompt dispatch ensure that research timelines are supported without delay. We maintain consistent stock availability and offer competitive pricing to support both individual investigators and institutional purchasing programs. Order now to benefit from our quality-assured supply chain and dedicated customer support team.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. TRH Thyrotropin (Protirelin) is sold exclusively as a laboratory research material. It has not been evaluated or approved by any regulatory authority for therapeutic, prophylactic, or diagnostic use in humans or animals. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the acquisition, storage, and use of synthetic peptide research compounds. The Peptide Store assumes no liability for misuse or use outside of the stated research context.