TRH Thyrotropin (Protirelin) 50mg

TRH Thyrotropin (Protirelin) is a synthetic tripeptide analog of thyrotropin-releasing hormone, manufactured to ≥98% purity and supplied exclusively for laboratory and scientific research applications. This compound is of significant interest in endocrine signaling, hypothalamic pathway modeling, and neuropeptide receptor studies. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

TRH Thyrotropin (Protirelin) is a well-characterized synthetic tripeptide that mirrors the structure of endogenous thyrotropin-releasing hormone produced in the hypothalamus. In research contexts, Protirelin is primarily examined for its role in stimulating TSH release from the anterior pituitary under controlled experimental conditions. Its compact molecular architecture and clearly defined receptor interaction profile make it a highly sought-after compound among endocrinologists, neurobiologists, and pharmacologists working within regulated laboratory environments. The Peptide Store supplies this compound to qualified researchers and institutions seeking consistent, high-purity material for advanced investigative work.

Peptide Structure & Amino Acid Sequence

Protirelin is a synthetic tripeptide comprising three amino acid residues: pyroglutamic acid, histidine, and prolineamide, typically represented as pGlu-His-Pro-NH₂. This sequence is identical to the naturally occurring thyrotropin-releasing hormone and is notable for its resistance to enzymatic degradation relative to linear peptides of similar size. The pyroglutamate N-terminus and C-terminal amidation both contribute to the molecule’s stability and receptor-binding efficiency, making it a reliable model compound for receptor affinity studies and hypothalamic-pituitary axis research.

Chemical & Physical Characteristics

• Common Name: Protirelin / TRH / Thyrotropin-Releasing Hormone
• CAS Number: 24305-27-9
• Molecular Formula: C₁₆H₂₂N₆O₄
• Molecular Weight: 362.38 g/mol
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in aqueous buffers and sterile water under laboratory conditions
• Storage Stability: Stable under recommended laboratory storage conditions

These properties collectively support Protirelin’s utility as a reference compound in biochemical assays, receptor binding experiments, and in vitro cell-based signaling studies.

Purity & Analytical Verification (HPLC & MS)

Every batch of TRH Thyrotropin (Protirelin) supplied by The Peptide Store is manufactured to a minimum purity of ≥98%, verified through high-performance liquid chromatography (HPLC). Mass spectrometry (MS) analysis is additionally employed to confirm the correct molecular weight and structural identity of the compound. These dual analytical methods ensure that researchers receive a product that meets the rigorous standards required for reproducible, publication-quality experimental data. Analytical certificates are available upon request for qualified laboratory purchasers.

Quality Control & Lyophilization Integrity

Protirelin is produced under stringent quality control protocols, encompassing raw material sourcing, synthesis, purification, and final formulation. The compound is lyophilized — a freeze-drying process that removes residual moisture while preserving molecular integrity — resulting in a stable, easily handled powder that maintains potency throughout its shelf life when stored correctly. Lyophilization also facilitates accurate weighing and preparation for in vitro research applications, reducing variability between experimental runs and supporting consistent laboratory outcomes.

Safety, Handling & Laboratory Precautions

As with all research peptides, appropriate laboratory safety protocols must be followed when handling TRH Thyrotropin (Protirelin). Researchers should wear suitable personal protective equipment (PPE) including gloves, eye protection, and a laboratory coat. The compound should be handled in a clean, controlled environment to prevent contamination. Avoid inhalation of powder and contact with skin or mucous membranes. This product is strictly intended for in vitro and qualified laboratory research use only and must not be administered to humans or animals under any circumstances.

Reconstitution, Packaging & Storage

TRH Thyrotropin (Protirelin) is supplied as a lyophilized powder in sealed, research-grade vials designed to protect compound integrity during transit and storage. For laboratory reconstitution purposes, researchers should consult peer-reviewed literature and established laboratory protocols appropriate to their specific experimental design. The product should be stored in a cool, dry environment, away from direct light and moisture. Long-term storage is recommended at -20°C or below, with short-term storage at 4°C acceptable for active research periods. Avoid repeated freeze-thaw cycles to maintain compound stability.

Intended Research Use & Market Positioning

Protirelin (TRH) occupies an important niche within the research peptide market due to its well-established role in hypothalamic-pituitary-thyroid (HPT) axis signaling studies. It is widely used as a positive control compound in TSH stimulation assays, as a reference ligand in TRH receptor binding experiments, and as a model peptide in neuropeptide pharmacology research. The Peptide Store positions this compound as a premium, analytically verified research material for academic institutions, pharmaceutical research organizations, and independent contract research laboratories seeking reliable, competitively priced peptide reagents.

Ordering, Availability & Fulfillment

Researchers and laboratory procurement teams can order TRH Thyrotropin (Protirelin) directly through The Peptide Store’s secure online platform. We offer competitive pricing, fast order processing, and reliable domestic and international fulfillment to qualified research institutions. Our streamlined ordering system makes it straightforward to buy research peptides online with confidence. For bulk purchasing inquiries or institutional account arrangements, please contact our customer service team directly. All orders are dispatched with appropriate documentation to support laboratory compliance requirements.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. TRH Thyrotropin (Protirelin) is sold exclusively as a laboratory research reagent. The Peptide Store makes no representations regarding the suitability of this compound for any application beyond qualified scientific research conducted by trained professionals in appropriately equipped facilities. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international regulations governing the acquisition, storage, and use of research peptides and chemical reagents. This product is not a drug, supplement, or therapeutic agent and has not been evaluated or approved by any regulatory authority for human or animal use.