TB-500 Fragment (17-23) 10mg

TB-500 Fragment (17-23) is a precision-engineered research peptide representing the active actin-binding domain of the Thymosin Beta-4 (Tβ4) molecule. Available at ≥98% purity in lyophilized form, this compound is intended exclusively for qualified laboratory and in vitro research applications. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

TB-500 Fragment (17-23) is a truncated, functionally isolated segment of the full 43-amino acid Thymosin Beta-4 protein. Researchers have long studied the parent molecule for its role in actin sequestration and cellular motility; however, the (17-23) fragment has emerged as the minimal bioactive unit responsible for these key molecular interactions. By isolating this domain, laboratory scientists can interrogate specific mechanistic pathways without the confounding variables introduced by the full-length protein. The Peptide Store offers this compound in a research-grade, lyophilized format, manufactured to the highest quality standards to support reproducible experimental outcomes.

Peptide Structure & Amino Acid Sequence

The TB-500 Fragment (17-23) corresponds to the heptapeptide sequence Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln, representing residues 17 through 23 of the native Thymosin Beta-4 polypeptide chain. This N-terminally acetylated sequence constitutes the core actin-binding motif of Tβ4 and is recognized in peer-reviewed literature as the primary functional domain governing G-actin sequestration and cell migration signaling. Its compact, well-defined structure makes it an ideal tool for structure-activity relationship (SAR) studies in regenerative biology and molecular biophysics research.

Chemical & Physical Characteristics

• Peptide Name: TB-500 Fragment (17-23)
• Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln
• Molecular Formula: C₃₃H₆₀N₈O₁₂
• Molecular Weight: Approximately 764.87 g/mol
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in aqueous buffers under standard laboratory conditions
• Purity: ≥98% by HPLC analysis
• Storage Condition: −20°C recommended for long-term stability

Purity & Analytical Verification (HPLC & MS)

Every batch of TB-500 Fragment (17-23) supplied by The Peptide Store undergoes rigorous analytical testing prior to release. High-Performance Liquid Chromatography (HPLC) is employed to confirm a minimum purity threshold of ≥98%, while Mass Spectrometry (MS) verification confirms the correct molecular identity and sequence integrity of each lot. These dual-verification protocols ensure that researchers receive a compound of consistent, publication-grade quality suitable for demanding in vitro experimental designs.

Quality Control & Lyophilization Integrity

Lyophilization—or freeze-drying—is the preferred preservation method for sensitive peptide compounds such as TB-500 Fragment (17-23). This process removes residual moisture under controlled vacuum conditions, significantly extending shelf life and preserving structural integrity. Each unit produced at The Peptide Store is lyophilized under validated conditions and sealed in an inert, moisture-resistant container to prevent degradation during transit and storage. Batch-specific Certificates of Analysis (CoA) are available upon request, providing full traceability for research documentation purposes.

Safety, Handling & Laboratory Precautions

TB-500 Fragment (17-23) is a research-grade chemical compound and must be handled exclusively by trained laboratory personnel in accordance with applicable institutional safety protocols. Appropriate personal protective equipment (PPE), including gloves, laboratory coat, and eye protection, should be worn at all times when handling this material. This compound is not intended for administration to humans or animals under any circumstances. Researchers should consult applicable Safety Data Sheets (SDS) and institutional biosafety guidelines before commencing any experimental work involving this peptide.

Reconstitution, Packaging & Storage

TB-500 Fragment (17-23) is supplied as a lyophilized powder in a sealed vial suitable for standard laboratory reconstitution procedures using research-grade solvents as appropriate for the specific experimental protocol. All reconstitution must be performed under sterile laboratory conditions by qualified researchers. For optimal stability, the lyophilized product should be stored at −20°C and protected from light and repeated freeze-thaw cycles. Once reconstituted, solutions should be aliquoted and stored according to established laboratory best practices to maintain compound integrity throughout the research period.

Intended Research Use & Market Positioning

TB-500 Fragment (17-23) is positioned as a high-purity, single-domain research tool for scientists investigating actin dynamics, cellular migration mechanisms, and the molecular biology of tissue remodeling at the in vitro level. Its narrow functional specificity makes it particularly valuable in studies designed to delineate the contribution of the Tβ4 actin-binding domain from other functional regions of the parent molecule. The Peptide Store supplies this compound to academic institutions, biotechnology research groups, and independent laboratories seeking a reliable, competitively priced source for this specialized fragment peptide.

Ordering, Availability & Fulfillment

TB-500 Fragment (17-23) is available to order online through The Peptide Store with fast, reliable fulfillment and competitive pricing. Researchers looking to buy TB-500 Fragment (17-23) for sale at the best price will find our streamlined ordering process, transparent CoA documentation, and dedicated customer support make The Peptide Store the preferred supplier for research peptides. Order now to take advantage of our current stock availability and ensure uninterrupted supply for your ongoing research programs.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. TB-500 Fragment (17-23) is sold exclusively as a laboratory research reagent. The Peptide Store makes no claims regarding therapeutic efficacy, biological safety for administration, or suitability for any use beyond controlled in vitro research. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international regulations governing the purchase, storage, and use of research peptides. This product must not be used as a drug, food additive, or dietary supplement.