TB-500 (Thymosin Beta-4) 5mg (43aa)

TB-500 (Thymosin Beta-4) is a synthetic, full-length 43-amino acid research peptide produced at ≥98% purity, designed for advanced laboratory investigation into cellular migration, actin sequestration, and tissue modeling. Available exclusively at The Peptide Store for qualified researchers and institutions. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

TB-500 (Thymosin Beta-4) is the complete, full-length synthetic representation of the endogenous 43-amino acid protein found across virtually all mammalian cell types. Unlike truncated analogs or shorter fragment sequences, this full 43aa construct encompasses the entire functional architecture of the native Thymosin Beta-4 molecule. It is widely recognized in the biochemical research community as one of the most studied G-actin sequestering peptides, making it a valuable compound for researchers investigating cytoskeletal dynamics, cellular repair mechanisms, and tissue remodeling pathways. The Peptide Store supplies this compound in lyophilized form to preserve structural integrity for precise experimental application.

Peptide Structure & Amino Acid Sequence

TB-500 is a 43-amino acid peptide with the sequence corresponding to the full-length human Thymosin Beta-4 protein. Its molecular structure includes a central actin-binding domain — the LKKTET motif — which is responsible for its well-documented interaction with globular actin (G-actin). The full-length sequence distinguishes this compound from shorter synthetic fragments, providing researchers access to the complete molecular architecture necessary for studying the peptide’s broad range of biochemical interactions. The 43aa chain supports investigation of secondary structure formation, including alpha-helical regions relevant to protein-protein interaction studies.

Chemical & Physical Characteristics

• Peptide Name: TB-500 (Thymosin Beta-4)
• Sequence Length: 43 Amino Acids (43aa)
• Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
• Molecular Weight: Approximately 4,963 Da
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in aqueous buffers; refer to institutional laboratory protocols
• Storage Condition: −20°C recommended for long-term stability
• Purity: ≥98% as verified by HPLC and mass spectrometry

Purity & Analytical Verification (HPLC & MS)

Every batch of TB-500 supplied by The Peptide Store undergoes rigorous analytical verification to confirm ≥98% purity. High-performance liquid chromatography (HPLC) is used to assess peptide homogeneity and detect any residual impurities or synthesis by-products. Mass spectrometry (MS) is applied to confirm the precise molecular weight and validate the correct amino acid composition of the full 43aa sequence. These dual verification methods ensure that researchers receive a compound of consistent quality and reproducible performance across experimental protocols.

Quality Control & Lyophilization Integrity

TB-500 is manufactured under stringent quality control conditions and supplied in its lyophilized (freeze-dried) state. Lyophilization is the preferred preservation method for complex peptides of this length, as it removes residual moisture while maintaining the structural integrity of the secondary and tertiary conformations within the 43-amino acid chain. Each vial is sealed under inert atmospheric conditions to prevent oxidative degradation. Lot-specific certificates of analysis (CoA) are available upon request, providing full traceability for institutional procurement and research documentation purposes.

Safety, Handling & Laboratory Precautions

TB-500 is intended strictly for in vitro and preclinical research use by trained laboratory professionals. Standard laboratory safety protocols must be followed when handling this compound, including the use of appropriate personal protective equipment (PPE) such as gloves, eye protection, and lab coats. Researchers should consult their institution’s safety data guidelines before use. This compound is not approved for any human or animal administration and must be handled in accordance with applicable institutional biosafety regulations.

Reconstitution, Packaging & Storage

TB-500 is supplied as a lyophilized powder in a sealed research-grade vial. Reconstitution should be performed using sterile, research-grade solvents in accordance with established laboratory protocols specific to the intended assay or experimental design. Once reconstituted, the solution should be aliquoted and stored appropriately to minimize freeze-thaw cycles. Lyophilized stock should be stored at −20°C and shielded from light and humidity. Reconstituted solutions should be used promptly or stored at −80°C for short-term retention, following institutional guidelines.

Intended Research Use & Market Positioning

TB-500 (Thymosin Beta-4) is positioned as a premium research tool for scientists studying cytoskeletal organization, G-actin sequestration, cellular migration, angiogenesis models, and extracellular matrix interactions. Its pleiotropic profile makes it relevant across multiple research disciplines including cell biology, molecular pharmacology, and regenerative science. The Peptide Store supplies this compound to academic institutions, contract research organizations (CROs), and independent research laboratories seeking a high-purity, analytically verified peptide for advanced experimental work.

Ordering, Availability & Fulfillment

TB-500 (Thymosin Beta-4) is available to buy online directly through The Peptide Store. We offer competitive best-price positioning with streamlined order processing and reliable fulfillment for domestic and international research customers. All orders are dispatched with full documentation, including CoA references where applicable. Order now to secure your research supply with confidence from a trusted peptide supplier committed to quality and compliance.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. TB-500 (Thymosin Beta-4) sold by The Peptide Store is intended exclusively for in vitro laboratory research conducted by qualified professionals in appropriate research settings. This product has not been evaluated or approved by any regulatory authority for therapeutic, diagnostic, or consumer use. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international regulations governing the procurement and use of research peptides. The Peptide Store assumes no liability for misuse or unauthorized application of this compound.