ARA-290 16mg

ARA-290 (Cibinetide) is a premium-grade, synthetic 11-amino-acid peptide analogue derived from the non-erythropoietic helix B surface domain of erythropoietin (EPO), supplied by The Peptide Store at ≥98% purity. Engineered as a precision biochemical research tool, ARA-290 enables rigorous investigation of innate repair receptor (IRR) activation, paracrine signaling, and chronic neuropathic inflammation modulation without influencing hematocrit levels. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

ARA-290, also widely referenced in the scientific literature under the name Cibinetide, represents one of the most structurally precise EPO-derived peptide analogues available for laboratory acquisition. Unlike full-length erythropoietin, ARA-290 is selectively engineered to engage the innate repair receptor complex — a heterodimer composed of the EPO receptor and the beta common receptor (βcR) — while remaining entirely inert with respect to classical erythropoietic signaling. This functional selectivity makes ARA-290 an invaluable molecular probe for researchers investigating tissue protection, neuroinflammation, and metabolic pathway modulation at the cellular and molecular level.

Peptide Structure & Amino Acid Sequence

ARA-290 is a linear, 11-amino-acid synthetic peptide with the following sequence: L-Glutamyl–L-Glutamyl–L-Leucyl–L-Prolyl–L-Aspartyl–L-Valinyl–L-Tyrosyl–L-Isoleucyl–L-Isoleucyl–L-Glutamyl–L-Lysine. This sequence corresponds directly to the helix B surface domain loop of the EPO molecule — a region identified in peer-reviewed structural biology research as the primary locus responsible for tissue-protective and anti-inflammatory receptor engagement. The linear configuration ensures consistent folding behavior and reproducible receptor-binding kinetics under controlled laboratory conditions, making ARA-290 a highly dependable tool for in vitro and ex vivo experimental protocols.

Chemical & Physical Characteristics

• Peptide Type: Synthetic linear 11-amino-acid analogue
• Origin: EPO helix B surface domain
• Molecular Target: Innate Repair Receptor (IRR / EPO-R / βcR heterodimer)
• Erythropoietic Activity: None — fully non-erythropoietic
• Physical Form: Lyophilized white to off-white powder
• Solubility: Soluble in aqueous buffers; compatible with standard laboratory reconstitution solvents
• Storage Stability: Stable under recommended cold-chain storage conditions

Purity & Analytical Verification (HPLC & MS)

Every batch of ARA-290 supplied by The Peptide Store is independently verified to a minimum purity of ≥98% using reverse-phase high-performance liquid chromatography (RP-HPLC). Complementary mass spectrometry (MS) analysis confirms precise molecular weight integrity and sequence fidelity, ensuring that each vial delivered to the researcher contains a chemically authentic, contaminant-minimized compound. Certificates of Analysis (CoA) reflecting these analytical results are available upon request, supporting full traceability and experimental reproducibility.

Quality Control & Lyophilization Integrity

ARA-290 is manufactured under stringent quality control protocols and subjected to lyophilization — a freeze-drying process that removes residual moisture under vacuum conditions — to maximize long-term stability and shelf life. Lyophilization preserves peptide structural integrity during storage and transit, reducing the risk of degradation from hydrolysis or oxidative exposure. Each vial undergoes final QC inspection prior to dispatch to ensure seal integrity, accurate fill weight, and compliance with documented purity specifications.

Safety, Handling & Laboratory Precautions

ARA-290 is intended exclusively for use by qualified researchers in properly equipped laboratory environments. Appropriate personal protective equipment (PPE), including gloves, lab coat, and eye protection, should be worn at all times during handling. This compound should be stored away from incompatible materials, excessive heat, and direct UV light. Standard laboratory biosafety practices applicable to synthetic peptide reagents must be observed. This material is not evaluated for safety in biological systems and must never be used in any human or animal subject.

Reconstitution, Packaging & Storage

ARA-290 is supplied as a lyophilized powder in a sealed, sterile vial suitable for laboratory reconstitution using appropriate research-grade solvents such as sterile water or phosphate-buffered saline (PBS), depending on experimental requirements. Reconstituted solutions should be aliquoted promptly and stored at –20°C or below to prevent degradation. Lyophilized stock should be stored at 2–8°C with desiccant and protected from light. Avoid repeated freeze-thaw cycles to maintain solution integrity across experimental sessions.

Intended Research Use & Market Positioning

ARA-290 is positioned as a leading-edge research reagent for academic institutions, pharmaceutical research organizations, and independent laboratories engaged in the study of neuropathic pain mechanisms, tissue cytoprotection, metabolic inflammation, and innate immune receptor pharmacology. Its unique non-erythropoietic EPO-derived structure fills a critical gap in the research toolkit for scientists seeking to decouple EPO’s hematopoietic functions from its tissue-protective signaling axis. The Peptide Store offers ARA-290 at a competitive best price, backed by verified analytical documentation and reliable fulfillment infrastructure.

Ordering, Availability & Fulfillment

ARA-290 16mg is available to order now directly through The Peptide Store’s secure online platform. We maintain consistent stock availability to support ongoing research timelines without interruption. Orders are processed promptly, with cold-chain-compliant packaging ensuring product integrity throughout transit. Researchers seeking to buy ARA-290 online benefit from our streamlined checkout process, transparent CoA documentation, and dedicated customer support for research procurement inquiries.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. ARA-290 is sold exclusively as a laboratory research reagent. It has not been approved by any regulatory authority for therapeutic, prophylactic, or diagnostic use in humans or animals. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the acquisition, possession, and use of research peptides. The Peptide Store assumes no liability for misuse, improper handling, or any application of this compound outside of its intended research context.