Melanotan 2 (MT2) 10mg

Melanotan 2 (MT-II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), produced at ≥98% purity and supplied by The Peptide Store as a precision-grade lyophilized research compound. Engineered for advanced laboratory investigations into melanocortin receptor pharmacology, GPCR signaling cascades, and neuroendocrine feedback dynamics, this formulation delivers exceptional structural stability and analytical consistency. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

Melanotan 2 (MT-II) is one of the most extensively studied synthetic melanocortin peptides in contemporary pharmacological research. As a potent, structurally optimized analog of the endogenous neuropeptide α-MSH, MT-II has become a cornerstone reference compound in laboratories investigating melanocortin system biology, G-protein-coupled receptor (GPCR) signaling, and neuroendocrine regulation. The Peptide Store supplies this compound in lyophilized cake form, manufactured to the highest research-grade specifications, making it a preferred choice for scientists seeking reliable, reproducible experimental results.

Peptide Structure & Amino Acid Sequence

Melanotan 2 is a cyclic heptapeptide with the confirmed amino acid sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2. This cyclization is achieved via a lactam bridge between the aspartic acid and lysine residues, a structural feature that confers exceptional conformational rigidity. The incorporation of D-phenylalanine at position four and norleucine at the N-terminus further distinguishes MT-II from its linear endogenous counterpart, enhancing both receptor selectivity and resistance to enzymatic degradation by serum peptidases. This structural architecture makes Melanotan 2 a highly stable and pharmacologically active scaffold for receptor-binding and signaling studies.

Chemical & Physical Characteristics

Melanotan 2 presents as a white to off-white lyophilized powder with the following key physicochemical properties:

• Molecular Formula: C₅₀H₆₉N₁₅O₉
• Molecular Weight: 1024.18 g/mol
• CAS Number: 121062-08-6
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
• Structure: Cyclic heptapeptide with lactam bridge
• Appearance: White to off-white lyophilized cake or powder
• Solubility: Soluble in aqueous buffers and dilute acetic acid solutions

These characteristics make MT-II well-suited for a range of in vitro assay formats and receptor pharmacology platforms used in academic and institutional research settings.

Purity & Analytical Verification (HPLC & MS)

Every batch of Melanotan 2 supplied by The Peptide Store undergoes rigorous analytical verification prior to release. Purity is confirmed at ≥98% using reverse-phase high-performance liquid chromatography (RP-HPLC), with identity further validated by mass spectrometry (MS). These dual-verification methods ensure that researchers receive a compound of defined chemical identity, free from significant impurities, degradation products, or synthesis-related byproducts. Certificates of Analysis (CoA) are available and reflect batch-specific purity and identity data, supporting full experimental traceability.

Quality Control & Lyophilization Integrity

Lyophilization is employed to maximize the long-term stability of Melanotan 2 under standard laboratory storage conditions. The freeze-drying process removes residual moisture while preserving the peptide’s native conformation and biological activity profile, ensuring that each vial maintains its chemical integrity from the point of manufacture through to experimental use. Our quality control pipeline includes multi-stage in-process testing and final release testing against defined specifications, ensuring batch-to-batch consistency for longitudinal research programs.

Safety, Handling & Laboratory Precautions

Melanotan 2 is supplied exclusively for qualified research use in controlled laboratory environments. Personnel handling this compound should adhere to standard laboratory safety protocols, including the use of appropriate personal protective equipment (PPE) such as gloves, eye protection, and lab coats. This compound should be handled only by trained scientific professionals in compliance with institutional biosafety guidelines. It is not intended for self-administration or any form of human or animal exposure outside of formally approved research protocols.

Reconstitution, Packaging & Storage

Melanotan 2 is packaged in pharmaceutical-grade sealed vials, suitable for standard laboratory handling and storage. For optimal stability, lyophilized material should be stored at -20°C in a dry, dark environment. Once reconstituted in an appropriate aqueous vehicle for in vitro research applications, working solutions should be aliquoted and stored at -80°C to minimize freeze-thaw degradation. Reconstitution protocols should be determined by qualified laboratory personnel in accordance with the specific assay requirements of the intended research application.

Intended Research Use & Market Positioning

Melanotan 2 is widely used in academic, pharmaceutical, and institutional research settings for the investigation of melanocortin receptor subtypes (MC1R–MC5R), GPCR signal transduction pathways, neuroendocrine regulatory mechanisms, and pigmentation biology. Its high receptor affinity and structural stability make it an ideal tool compound for competitive binding assays, functional cAMP accumulation studies, and structure-activity relationship (SAR) investigations. The Peptide Store positions MT-II as a premium, research-grade reference peptide for scientists requiring verified purity and reliable sourcing.

Ordering, Availability & Fulfillment

Melanotan 2 (MT-II) is available for sale online through The Peptide Store with fast, reliable fulfillment for qualified research institutions and laboratories worldwide. Order now to benefit from competitive pricing, batch-specific CoA documentation, and professional customer support. Our streamlined ordering process ensures prompt dispatch, with packaging designed to maintain cold-chain integrity during transit. Buy online today and experience the quality and consistency that research professionals trust.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Melanotan 2 (MT-II) is sold exclusively as a laboratory research reagent. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the purchase, possession, and use of research peptides. The Peptide Store makes no representations regarding the safety, efficacy, or suitability of this compound for any use beyond formally sanctioned scientific research conducted by qualified professionals in appropriately licensed facilities.