MOTS-c 10mg

MOTS-c 10mg is a mitochondria-derived, 16-amino-acid signaling peptide available at ≥98% purity, rigorously verified by HPLC and mass spectrometry. Sourced and supplied by The Peptide Store exclusively for qualified laboratory and research applications. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

MOTS-c — short for Mitochondrial Open Reading Frame of the 12S rRNA-c — is a groundbreaking mitochondria-encoded peptide that has attracted significant scientific interest for its role in systemic metabolic regulation. Unlike the vast majority of bioactive peptides, which are encoded within the nuclear genome, MOTS-c is uniquely transcribed from mitochondrial DNA. This distinction positions it as a critical subject of inquiry in mitochondrial biology, metabolic homeostasis, and cellular energy research. Researchers seeking to buy MOTS-c online will find The Peptide Store’s offering to be among the most rigorously quality-controlled options currently for sale.

Peptide Structure & Amino Acid Sequence

MOTS-c is a 16-amino-acid peptide with the sequence: MRWQEMGYIFYPRKLR. It is encoded within the mitochondrial 12S rRNA gene and is considered a mitochondrial-derived peptide (MDP). Its compact yet functionally dense structure allows it to translocate from mitochondria to the nucleus under conditions of metabolic stress, where it modulates gene expression pathways associated with energy metabolism. The peptide’s unique mitochondrial origin makes it a compelling candidate for studies exploring the intersection of organelle communication and whole-body metabolic signaling.

Chemical & Physical Characteristics

• Peptide Name: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
• Sequence: MRWQEMGYIFYPRKLR
• Amino Acid Count: 16 residues
• Molecular Formula: C₁₀₆H₁₅₉N₂₉O₂₄S₁
• Molecular Weight: Approximately 2,174.7 Da
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in aqueous buffers; research-grade solvent compatibility recommended
• Origin: Mitochondrial genome-encoded peptide

Purity & Analytical Verification (HPLC & MS)

Every batch of MOTS-c 10mg supplied by The Peptide Store undergoes comprehensive analytical testing prior to release. Purity is confirmed at ≥98% using reverse-phase high-performance liquid chromatography (RP-HPLC), and molecular identity is validated through mass spectrometry (MS). These dual-verification methods ensure that researchers receive a product of consistent quality and reliable composition — essential for reproducible experimental outcomes. A Certificate of Analysis (COA) reflecting these results is available upon request for every lot.

Quality Control & Lyophilization Integrity

MOTS-c 10mg is produced under stringent quality control protocols. Following synthesis and purification, the peptide undergoes lyophilization — a controlled freeze-drying process that removes residual moisture while preserving molecular integrity. This process ensures long-term stability and protects the peptide’s bioactive structure during storage and transit. Each unit is sealed under inert conditions to prevent oxidation and contamination, maintaining research-grade quality from production through delivery.

Safety, Handling & Laboratory Precautions

MOTS-c 10mg is intended exclusively for in vitro and qualified laboratory research settings. Personnel handling this compound should follow standard laboratory safety protocols, including the use of appropriate personal protective equipment (PPE) such as gloves, lab coats, and eye protection. This peptide has not been evaluated for safety in humans or animals. Researchers should consult applicable institutional biosafety guidelines before initiating any experimental work involving this compound.

Reconstitution, Packaging & Storage

MOTS-c 10mg is supplied as a lyophilized powder in a sealed, research-grade vial. For laboratory reconstitution purposes, researchers should refer to peer-reviewed literature and institutional protocols appropriate for their specific experimental design. Recommended storage conditions are as follows:

• Long-term storage: −20°C or below, away from light and moisture
• Short-term storage: 2–8°C in a sealed container, minimizing freeze-thaw cycles
• Reconstituted solution: Use promptly or aliquot and store at −20°C to preserve integrity

Proper storage is critical to maintaining the peptide’s analytical-grade quality and ensuring reliable experimental data.

Intended Research Use & Market Positioning

MOTS-c is a premier subject of investigation in laboratories studying AMPK (AMP-activated protein kinase) activation, mitochondrial homeostasis, insulin sensitivity, cellular stress response, and aging biology. As scientific interest in mitochondrial-derived peptides continues to expand, MOTS-c has emerged as one of the most studied MDPs in the field. The Peptide Store offers this compound competitively priced for qualified research buyers seeking the best price without compromising on analytical standards.

Ordering, Availability & Fulfillment

Researchers can order MOTS-c 10mg online directly through The Peptide Store with confidence. Our fulfillment process is streamlined for speed and discretion, with orders processed promptly and shipped in secure, tamper-evident packaging. Bulk inquiry options may be available for institutional or high-volume research buyers. Our customer support team is available to assist with documentation, COA requests, and order tracking. Order now to take advantage of current availability and competitive pricing.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. MOTS-c 10mg is sold exclusively as a laboratory research reagent. It has not been approved by any regulatory authority for therapeutic, prophylactic, or diagnostic use in humans or animals. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the procurement, storage, and use of research peptides. The Peptide Store assumes no liability for misuse or unauthorized application of this product.