FOX04-DRI 10mg (Proxofim)

FOXO4-DRI 10mg (Proxofim) is a premium-grade synthetic retro-inverso peptide manufactured to ≥98% purity, engineered for advanced senolytic, cellular longevity, and tissue regeneration research. Available for sale at The Peptide Store, this compound serves as a precise biochemical tool for investigating p53-FOXO4 interactome disruption and selective senescent cell apoptosis dynamics. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

FOXO4-DRI, also classified biochemically as Proxofim, is a customized D-amino acid retro-inverso (DRI) peptide designed to function as a high-resolution molecular probe in senolytic and cellular aging research. Senescent cells — often described as dysfunctional cells that evade natural clearance mechanisms — accumulate in aging tissue and contribute to systemic decline. FOXO4-DRI was engineered specifically to study the selective elimination of these cells by disrupting the interaction between the FOXO4 transcription factor and the tumor suppressor protein p53, a pathway implicated in the survival of senescent cells. Researchers investigating cellular longevity, tissue homeostasis, and age-related pathology will find this compound an indispensable laboratory reagent. Order now from The Peptide Store and access one of the most studied senolytic peptide tools available for in vitro and in vivo experimental models.

Peptide Structure & Amino Acid Sequence

FOXO4-DRI is structurally defined by its retro-inverso configuration — a sophisticated peptide engineering approach in which both the chirality of each amino acid residue is inverted (from L- to D-form) and the sequence direction is reversed. This dual modification preserves the critical side-chain topology required for target engagement while producing a mirror-image backbone that is unrecognizable to native proteolytic enzymes. The result is a synthetic peptide that mimics the biological binding surface of its L-amino acid counterpart with markedly superior metabolic stability. The retro-inverso architecture makes FOXO4-DRI particularly valuable in research contexts where prolonged experimental half-life and resistance to enzymatic degradation are essential variables, such as longitudinal cell culture assays and complex tissue model studies.

Chemical & Physical Characteristics

FOXO4-DRI (Proxofim) is supplied as a white to off-white lyophilized powder. Key physicochemical attributes include:

• Peptide Type: Synthetic D-amino acid retro-inverso (DRI) peptide
• Purity: ≥98% (confirmed by HPLC)
• Molecular Configuration: Retro-inverso; D-amino acid backbone
• Physical Form: Lyophilized powder
• Appearance: White to off-white solid
• Solubility: Soluble in aqueous buffers; consult technical documentation for solvent compatibility
• Storage Stability: Exceptional enzymatic resistance due to DRI structural modification

Purity & Analytical Verification (HPLC & MS)

Every batch of FOXO4-DRI 10mg available at The Peptide Store undergoes rigorous analytical verification to confirm identity and purity. High-Performance Liquid Chromatography (HPLC) is employed to quantify purity at ≥98%, ensuring that each unit meets the stringent standards required for reproducible scientific research. Mass Spectrometry (MS) analysis is additionally performed to confirm the correct molecular weight and structural integrity of the compound. Certificates of Analysis (CoA) are available upon request and reflect lot-specific analytical data, providing researchers with full traceability and confidence in the compound’s biochemical profile.

Quality Control & Lyophilization Integrity

FOXO4-DRI 10mg is produced under controlled manufacturing conditions with quality assurance protocols applied at every stage of synthesis and processing. Lyophilization is performed using validated freeze-drying cycles to remove residual moisture while preserving the structural and biochemical integrity of the peptide. The resulting lyophilized cake is visually inspected and tested for moisture content and reconstitution characteristics prior to release. This process ensures that the compound maintains its ≥98% purity specification throughout its shelf life when stored under recommended conditions.

Safety, Handling & Laboratory Precautions

FOXO4-DRI 10mg is intended exclusively for use by trained laboratory professionals in appropriately equipped research facilities. Standard laboratory safety practices must be observed at all times when handling this compound. Researchers should wear appropriate personal protective equipment (PPE), including gloves, lab coat, and eye protection. This material has not been evaluated for safety in humans or animals and must not be administered to any living organism. All waste must be disposed of in accordance with applicable institutional and regulatory guidelines for synthetic peptide materials.

Reconstitution, Packaging & Storage

FOXO4-DRI 10mg is packaged in a sealed, inert vial designed to protect the lyophilized peptide from moisture and environmental degradation. For reconstitution in a research setting, consult peer-reviewed literature and institutional protocols relevant to your specific experimental application. General guidance suggests compatibility with sterile aqueous buffers, but researchers must independently validate solvent systems for their assay conditions. Recommended storage is at -20°C in a dry, dark environment. Avoid repeated freeze-thaw cycles to preserve compound integrity. Once reconstituted, use promptly or aliquot and store according to validated laboratory procedures.

Intended Research Use & Market Positioning

FOXO4-DRI (Proxofim) occupies a unique position in the senolytic research landscape. Its retro-inverso architecture and demonstrated selectivity for disrupting the FOXO4-p53 survival axis in senescent cells make it a preferred research tool among scientists studying cellular aging, tissue regeneration, and age-associated pathology. It is widely referenced in peer-reviewed literature focused on senescence biology and is actively used in academic and private research institutions globally. The Peptide Store offers FOXO4-DRI 10mg for sale at a competitive best price, making this advanced research peptide accessible to qualified researchers worldwide.

Ordering, Availability & Fulfillment

FOXO4-DRI 10mg (Proxofim) is available to buy online directly from The Peptide Store. Orders are processed promptly, with fast dispatch and reliable international fulfillment options. All products are shipped in temperature-appropriate packaging to preserve peptide integrity during transit. Bulk ordering inquiries and institutional procurement requests are welcomed — contact our team for volume pricing and availability. Order now to secure your research supply of this high-demand senolytic peptide at the best price available.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. FOXO4-DRI 10mg (Proxofim) is sold exclusively as a laboratory research reagent. The Peptide Store makes no representations regarding the safety, efficacy, or suitability of this compound for any application outside of controlled laboratory research. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws and regulations governing the purchase, possession, and use of synthetic research peptides. This product has not been approved by any regulatory authority for therapeutic, diagnostic, or veterinary use.